Novel nuclear defects in KLP61F-deficient mutants inDrosophilaare partially suppressed by loss of Ncd function
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چکیده
منابع مشابه
nup1 mutants exhibit pleiotropic defects in nuclear pore complex function
The NUP1 gene of Saccharomyces cerevisiae encodes one member of a family of nuclear pore complex proteins (nucleoporins) conserved from yeast to vertebrates. We have used mutational analysis to investigate the function of Nup1p. Deletion of either the amino- or carboxy-terminal domain confers a lethal phenotype, but partial truncations at either end affect growth to varying extents. Amino-termi...
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15 صفحه اولMutants of the Drosophila ncd microtubule motor protein cause centrosomal and spindle pole defects in mitosis.
Nonclaret disjunctional (ncd) is a kinesin-related microtubule motor protein required for meiotic and early mitotic chromosome distribution in Drosophila. ncd translocates on microtubules with the opposite polarity to kinesin, toward microtubule minus ends, and is associated with spindles in chromosome/spindle preparations. Here we report a new mutant of ncd caused by partial deletion of the pr...
متن کاملA Homotetrameric Kinesin-5, KLP61F, Bundles Microtubules and Antagonizes Ncd in Motility Assays
BACKGROUND Mitosis depends upon the cooperative action of multiple microtubule (MT)-based motors. Among these, a kinesin-5, KLP61F, and the kinesin-14, Ncd, are proposed to generate antagonistic-sliding forces that control the spacing of the spindle poles. We tested whether purified KLP61F homotetramers and Ncd homodimers can generate a force balance capable of maintaining a constant spindle le...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2004
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.01334